Species Human Entrez 1072 | Human Mouse Ensembl ENSG00000172757 | |
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Aliases CFL1, CFL, HEL-S-15, cofilin, cofilin 1 External IDs OMIM: 601442 MGI: 101757 HomoloGene: 99735 GeneCards: CFL1 | ||
Gene music using protein sequence of cfl1 cofilin 1 non muscle
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.
Contents
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.
Interactions
Cofilin 1 has been shown to interact with HSPH1 and LIMK1.
References
Cofilin 1 Wikipedia(Text) CC BY-SA