Trisha Shetty (Editor)

LIMK1

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Species
  
Entrez
  
3984

Human
  
Ensembl
  
ENSG00000106683

LIMK1

Aliases
  
LIMK1, LIMK, LIMK-1, LIM domain kinase 1

External IDs
  
MGI: 104572 HomoloGene: 1738 GeneCards: LIMK1

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.

Contents

Function

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.

Clinical signficance

LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.

Interactions

LIMK1 has been shown to interact with:

  • CFL1,
  • CDKN1C,
  • NRG1,
  • PAK1,
  • PAK4, and
  • YWHAZ.
  • References

    LIMK1 Wikipedia


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