Entrez 1195 | Ensembl ENSG00000013441 | |
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Aliases CLK1, CLK, CLK/STY, STY, CDC like kinase 1 External IDs MGI: 107403 HomoloGene: 101535 GeneCards: CLK1 | ||
Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.
Contents
Function
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.
Interactions
CLK1 has been shown to interact with ASF/SF2.
References
CLK1 Wikipedia(Text) CC BY-SA