U.S. Marshal Mike Donovan (Vincent Cassel) (referred to as Broken Nose by the native tribe; unlike the comic his nickname is not Blueberry) has dark memories of the death of his first love. He keeps peace between the Americans and the natives who had temporarily adopted and taken care of him. The evil actions of Blount, a "white sorcerer" lead him to confront the villain in the Sacred Mountains, and, through shamanic rituals involving a native entheogenic brew, conquer his fears and uncover a suppressed memory he would much rather deny.Vincent Cassel as Mike Blueberry
Juliette Lewis as Maria Sullivan
Michael Madsen as Wallace Sebastian Blount
Temuera Morrison as Runi
Ernest Borgnine as Rolling Star
Djimon Hounsou as Woodhead
Hugh O'Conor as Young Mike Blueberry
Geoffrey Lewis as Greg Sullivan
Nichole Hiltz as Lola
Kateri Walker as Kateri
Vahina Giocante as Madeleine
Kestenbetsa as Kheetseen
Tchéky Karyo as Uncle
Eddie Izzard as Prosit
Colm Meaney as Jimmy McClure
François Levantal as Pete
Jean Giraud, the famous Franco-Belgian comics creator and the illustrator of the original Blueberry comics, appears in a cameo role in the film, while Geoffrey Lewis, who had appeared in several spaghetti Westerns and his daughter Juliette Lewis play a father and daughter in the movie.
The movie features several elaborate psychedelic 3D computer graphics sequences as a means of portraying Blueberry's shamanic experiences from his point of view. Jan Kounen, the director of the film, drew upon his extensive first hand knowledge of ayahuasca rituals in order to design the visuals for these sequences, Kounen having undergone the ceremony at least a hundred times with Shipibo language speakers in Peru. An authentic Shipibo ayahuasca guide appears in the film and performs a sacred chant. In the film, the exact nature of the entheogenic sacramental liquid which Blueberry (and his enemy, Blount) drink remains undisclosed. During the final visionary scene, however, there is a bowl of leaves shown accompanied by a twisting vine which is probably the ayahuasca vine, Banisteriopsis caapi. Historically, Native Americans living in the Southwest United States, would have had no geographic access to ayahuasca.
Peyote is shown growing in the sacred areas throughout the film, and the buttons are prominently displayed at the end, although the viewer cannot be sure what Runi offers to the Marshal either time.
Blueberry was not a critical success in the English-speaking world and received mostly negative reviews. It holds a 29% rating on Rotten Tomatoes and a score of 5.2 on IMDB.
Jamie Russell of the BBC felt the film was "two parts bonkers to one part boring", and compared the film to The Missing by describing it as "totally lost". In his review for Cinopsis, Eric Van Cutsem finds the film greatly disappoints the expectations of the large audiences of the original comic, being largely unrelated in both story and character. Raphaël Jullien of Abus de Cine felt the film's greatest weakness was that it is partly auteur experimentalism and partly genre western.
Some reviewers found praise for the film. Lisa Nesselson, writing for Variety was generally positive, noting the film demonstrated "one of the most mystical approaches to the Western this side of El Topo" and felt that the hallucinogenic climax of the film "may be the closest this generation will get to having its own variation on the "Stargate" sequence in Kubrick’s 2001: A Space Odyssey." Nesselson also noted, however, that the film "functions better as a purely visual journey than as the revelatory spiritual crucible it aspires to be".
The film has also managed to build a reputation as a cult success and as a trip film. French language cult cinema website Film de Culte awarded Blueberry 5-out-of-6, noting the unusual goal of the antagonist, "the treasure sought by Wally Blount is not gold hidden in Indian mountains, but the spirit that emerges" the quest of the protagonist as "a man in search of his identity, his roots, openness to the world and, why not, to love." Tetsuo Nagata's cinematography is also referred to as 'sublime'. Tripzine noted the film has "the best, most accurate, most lovingly crafted shamanic rituals and psychedelic visuals ever created for home viewing", and praised Blueberry's uniqueness among westerns for having a climax that revolved around shamanic ritual rather than a gun battle.