Trade names Canespor, many others ATC code D01AC10 (WHO) Molar mass 310.392 g/mol | Routes ofadministration Topical CAS Number 60628-96-8 | |
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AHFS/Drugs.com International Drug Names Legal status In general: Over-the-counter (OTC) | ||
Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade name Canespor in ointment form. Many other trade names exist.
Contents
There are also combinations with carbamide for the treatment of onychomycosis.
Adverse effects
The most common side effect is a burning sensation at the application site. Other reactions, such as itching, eczema or skin dryness, are rare.
Mechanism of action
Bifonazole has dual mode of action. It inhibits fungal ergosterol biosynthesis at two points, via transformation of 24-methylendihydrolanosterol to desmethylsterol, together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs.
Pharmacokinetics
Six hours after application, bifonazole concentrations range from 1000 µg/cm³ in the stratum corneum to 5 µg/cm³ in the papillary dermis.