Bernard Roizman is an American scientist born in Romania. He is the Joseph Regenstein Distinguished Service Professor of Virology in the Departments of Molecular Genetics & Cell Biology, Biochemistry & Molecular Biology, and in Microbiology. of Biological Sciences, at the University of Chicago.
Bernard Roizman received his B.A. and M.S. from Temple University, Philadelphia, Pennsylvania and subsequently attended the Johns Hopkins School of Public Health where he received his Sc.D.
Roizman is Joseph Regenstein Distinguished Service Professor of Virology in the Departments of Molecular Genetics & Cell Biology. He is also a faculty member in the Department of Biochemistry & Molecular Biology, and in Microbiology.
Awards and honors
Pasteur Award, Illinois Society of Microbiology, 1972;
Esther Langer Award, 1974.
Honorary Fellow, Pan American Cancer Cytology Soc., 1973;
Elected: Member of the National Academy of Sciences, 1979;
Outstanding Alumnus in Public Health Award for 1984 Johns Hopkins Univ;
Centennial Medal, Institut Pasteur, Paris, France 1987;
First annual ICN International Prize in Virology, 1988;
Society of Scholars, The Johns Hopkins University, 1988;
Fellow, Japanese Society for the Promotion of Science, 1989;
Fellow, American Academy of Arts and Sciences, 1991;
Sesquicentennial Gold Medal, University of Ferrara, Italy, 1991;
Fellow, American Academy of Microbiology, 1992;
Recipient, Bristol Myers Squibb Unsolicited Research Grant Award in Infectious Diseases, 1991–1995;
Honorary Member, Hungarian Academy of Sciences, 1995;
J. Allyn Taylor International Prize in Medicine, 1997;
Bristol-Myers Squibb Award for Distinguished Achievement in Infectious Disease Research, 1998;
Foreign Member, Chinese Academy of Engineering, 2000;
Institute of Medicine, 2001;
NIH Outstanding Investigator Award 1988-2001;
Honorary member, Italian Soc. for Virology, 2002;
NIH-NCI Merit award, 2003;
Quantrell Award for Excellence in undergraduate teaching, 2003;
Fellow, American Association for the Advancement of Science, 2004;
Abbott-ASM Lifetime Achievement Award, 2008;
Honorary degrees:
Doctorate in Humane Letters, Governors State University, IL. 1984;
Doctorate in Medicine and Surgery. University of Ferrara, Italy 1991;
Doctorate in Science, University of Paris, France, 1997;
Doctorate in Medicine, Univ. of Valladolid, Spain, 2001;
Professor (honoris causa) Shandong Academy of Medical Sciences, China, 1985;
Peking Union Medical College, China, 2002;
Shandong Univ, 2003;
Qingdao Univ. 2003;
Jiatong Univ Beijing 2007;
Journal articles
Roizman, Bernard; Honess, R.W (1974). "Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.". J. Virol. 114 (1): 8–19. PMC 355471. PMID 4365321.
Roizman, Bernard; Honess, R.W (1975). "Regulation of herpesvirus macromolecular synthesis: Sequential transition of polypeptide synthesis requires functional viral polypeptides". Proceedings of the National Academy of Sciences of the United States of America 72 (4): 1276–1280. Bibcode:1975PNAS...72.1276H. doi:10.1073/pnas.72.4.1276. PMID 165503.
Roizman, Bernard; Mocarski, E.S.; Post, L.E. (1980). "Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions.". Cell 22 (1 Pt 1): 243–255. doi:10.1016/0092-8674(80)90172-5. PMID 6253078.
Roizman, Bernard; Post, L.E.; Mackem, S. (1981). "Regulation of α genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters.". Cell 24 (2): 555–565. doi:10.1016/0092-8674(81)90346-9. PMID 6263501.
Roizman, Bernard; Post, L.E. (1981). "A generalized technique for deletion of specific genes in large genomes: α gene 22 of herpes simplex virus 1 is not essential for growth.". Cell 25 (1): 227–232. doi:10.1016/0092-8674(81)90247-6. PMID 6268303.
Roizman, Bernard; Sears, A.E.; Halliburton, I.W.; Meignier, B.; Silver, S. (1985). ". Herpes simplex virus mutant deleted in the α22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice.". J. Virol. 55 (2): 338–346. PMC 254938. PMID 2991560.
Roizman, Bernard; Jenkins, F.J. (1985). "Genetic engineering of novel genomes of large DNA viruses". Science 229 (4719): 1208–1218. Bibcode:1985Sci...229.1208R. doi:10.1126/science.2994215.
Roizman, Bernard; Purves, F. C.; Longnecker, R. M.; Leader, D. P. (1987). "The herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture". J. Virol. 61 (9): 2896–901. PMC 255814. PMID 3039176.
Roizman, Bernard; Purves, F.C. (1992). "The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein α22". Proceedings of the National Academy of Sciences of the United States of America 89 (16): 7310–314. Bibcode:1992PNAS...89.7310P. doi:10.1073/pnas.89.16.7310.
Roizman, Bernard; Michael, N. (1993). "Repression of the herpes simplex virus 1 α4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 286–290. Bibcode:1993PNAS...90.2286M. doi:10.1073/pnas.90.6.2286.
Roizman, Bernard; Andreansky, S., He, B., van Cott, J., McGhee, J. V., Markert, J.M., Whitley, R. (1998). "Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins". Gene Ther. 5 (1): 121–130. doi:10.1038/sj.gt.3300550. PMID 9536273.
Roizman, Bernard; Ogle, W. O. (1999). "Functional anatomy of the herpes simplex virus 1 overlapping genes encoding infected cell-protein 22 and US1.5 protein.". J. Virol. 73 (5): 4305–4315. PMC 104212. PMID 10196329.
Roizman, Bernard; Poon A.P.W. (2007). "Mapping of key functions of the herpes simplex virus 1 US3 protein kinase: the US3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides.". J. Virol. 81 (4): 1980–1998. doi:10.1128/JVI.02265-06. PMC 1797600. PMID 17151133.
Roizman, Bernard; Jovasevic, V.; Liang, L. (2008). "Proteolytic cleavage of VP1-2 is required for the release of herpes simplex virus 1 DNA into the nucleus.". J. Virol. 82 (7): 2211–2219. doi:10.1128/JVI.01919-07. PMC 2268474. PMID 18216103.
