Species Human Entrez 79184 | Human Mouse Ensembl ENSG00000185515 | |
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Aliases BRCC3, BRCC36, C6.1A, CXorf53, BRCA1/BRCA2-containing complex subunit 3 External IDs MGI: 2389572 HomoloGene: 11530 GeneCards: BRCC3 | ||
Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.
Contents
Function
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.
Interactions
BRCC3 has been shown to interact with BRE, BRCA2, RAD51, BRCA1, P53 and BARD1.
References
BRCC3 Wikipedia(Text) CC BY-SA