Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.
Contents
Arias-Stella reaction is due to progesterone primarily.
Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer.
Significance
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
Diagnosis
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.
Five subtypes are recognized:
- Minimal atypia.
- Early secretory pattern.
- Secretory or hypersecretory pattern.
- Regenerative, proliferative or nonsecretory pattern.
- Monstrous cell pattern.
History
It was first described by Javier Arias Stella, a Peruvian pathologist in 1954.
References
Arias-Stella reaction Wikipedia(Text) CC BY-SA