Molar mass 888.99 g/mol | Formula C34H60N14O12S | |
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Related compounds IUPAC ID (6S,9S,12S,15S,18S,21S)-21-acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic acid | ||
Acetyl hexapeptide-3 or acetyl hexapeptide-8 (sources differ) is a synthetic anti-wrinkle cosmetics ingredient. It is a peptide which is a fragment of SNAP-25, a substrate of Botulinum toxin (Botox). Acetyl hexapeptide-8 is marketed as Argireline by the Barcelona-based research laboratory Lipotec.
Contents
Overview and common uses
Argireline is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes.
Chemically, when applied as a solution to specific areas of the face, Argireline inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning.
Cosmetic studies
Both in vitro (outside a living organism) and in vivo (using a living organism) tests have been carried out on Argireline, but double-blind clinical trials results have not been published.
Safety research
Argireline has been developed relatively recently and therefore reports on its long-term use have not yet been produced.
Chemistry
Argireline is the hexapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2.