Kalpana Kalpana

ASCL2

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Species  Human
Entrez  430
Human  Mouse
Ensembl  ENSG00000183734
ASCL2
Aliases  ASCL2, ASH2, HASH2, MASH2, bHLHa45, achaete-scute family bHLH transcription factor 2
External IDs  MGI: 96920 HomoloGene: 3789 GeneCards: ASCL2

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.

Contents

Function

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Interactions

ASCL2 has been shown to interact with NCOA6 and RBBP5.

References

ASCL2 Wikipedia


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