Species Human Entrez 430 | Human Mouse Ensembl ENSG00000183734 | |
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Aliases ASCL2, ASH2, HASH2, MASH2, bHLHa45, achaete-scute family bHLH transcription factor 2 External IDs MGI: 96920 HomoloGene: 3789 GeneCards: ASCL2 | ||
Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.
Contents
Function
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Interactions
ASCL2 has been shown to interact with NCOA6 and RBBP5.
References
ASCL2 Wikipedia(Text) CC BY-SA