| ASCL2, ASH2, HASH2, MASH2, bHLHa45, achaete-scute family bHLH transcription factor 2|
MGI: 96920 HomoloGene: 3789 GeneCards: ASCL2
Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
ASCL2 has been shown to interact with NCOA6 and RBBP5.