Neha Patil

ARHGEF1

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Species  Human
Entrez  9138
Human  Mouse
Ensembl  ENSG00000076928
ARHGEF1
Aliases  ARHGEF1, GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, Rho guanine nucleotide exchange factor 1
External IDs  MGI: 1353510 HomoloGene: 3454 GeneCards: ARHGEF1

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.

Contents

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Interactions

ARHGEF1 has been shown to interact with:

  • CD44,
  • GNA12,
  • GNA13, and
  • P110α
  • References

    ARHGEF1 Wikipedia


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