Species Human Entrez 23365 | Human Mouse Ensembl ENSG00000196914 | |
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Aliases ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12 External IDs MGI: 1916882 HomoloGene: 9088 GeneCards: ARHGEF12 | ||
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.
Contents
Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.
Clinical significance
This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.
Interactions
ARHGEF12 has been shown to interact with:
References
ARHGEF12 Wikipedia(Text) CC BY-SA