Supriya Ghosh

ARHGEF12

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Species  Human
Entrez  23365
Human  Mouse
Ensembl  ENSG00000196914
ARHGEF12
Aliases  ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12
External IDs  MGI: 1916882 HomoloGene: 9088 GeneCards: ARHGEF12

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.

Contents

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

Clinical significance

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.

Interactions

ARHGEF12 has been shown to interact with:

References

ARHGEF12 Wikipedia


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