| ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12|
MGI: 1916882 HomoloGene: 9088 GeneCards: ARHGEF12
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.
This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.
ARHGEF12 has been shown to interact with: