| ARHGEF11, GTRAP48, PDZ-RHOGEF, Rho guanine nucleotide exchange factor 11|
MGI: 2441869 HomoloGene: 11409 GeneCards: ARHGEF11
Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
ARHGEF11 has been shown to interact with PLXNB3, PLXNB1, PLXNB2 and RHOA.