Species Human Entrez 11154 | Human Mouse Ensembl ENSG00000100478 | |
Aliases AP4S1, AP47B, CLA20, CLAPS4, CPSQ6, SPG52, adaptor related protein complex 4 sigma 1 subunit External IDs MGI: 1337065 HomoloGene: 32513 GeneCards: AP4S1 | ||
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene.
Contents
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1, this gene).
Clinical relevance
It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
AP4S1 Wikipedia(Text) CC BY-SA