Entrez 9179 | Ensembl ENSG00000221838 | |
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External IDs MGI: 1337063 HomoloGene: 3467 GeneCards: AP4M1 | ||
AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.
Contents
Function
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.
Interactions
AP4M1 has been shown to interact with AP4B1.
Clinical relevance
The AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
AP4M1 Wikipedia(Text) CC BY-SA