Samiksha Jaiswal

AP4M1

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Species  Human
Entrez  9179
Human  Mouse
Ensembl  ENSG00000221838
AP4M1
Aliases  AP4M1, CPSQ3, MU-4, MU-ARP2, SPG50, adaptor related protein complex 4 mu 1 subunit
External IDs  MGI: 1337063 HomoloGene: 3467 GeneCards: AP4M1

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.

Contents

Function

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.

Interactions

AP4M1 has been shown to interact with AP4B1.

Clinical relevance

The AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.

References

AP4M1 Wikipedia


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