Species Human Entrez 10717 | Human Mouse Ensembl ENSG00000134262 | |
Aliases AP4B1, BETA-4, CPSQ5, SPG47, adaptor related protein complex 4 beta 1 subunit External IDs MGI: 1337130 HomoloGene: 38203 GeneCards: AP4B1 | ||
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.
Contents
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1)
Interactions
AP4B1 has been shown to interact with AP4M1.
Clinical relevance
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
AP4B1 Wikipedia(Text) CC BY-SA