Entrez 8852 | Ensembl ENSG00000147081 | |
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Aliases AKAP4, AKAP 82, AKAP-4, AKAP82, CT99, FSC1, HI, PRKA4, hAKAP82, p82, A-kinase anchoring protein 4 External IDs MGI: 102794 HomoloGene: 2887 GeneCards: AKAP4 | ||
A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene.
Contents
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Clinical significance
AKAP4 is a potential biomarker for early diagnosis and immunotherapy of colon cancer. AKAP4 may be implicated as a biomarker and immunotherapeutic target for cervical cancer. AKAP4 is also a circulating biomarker for non-small cell lung cancer.
Interactions
AKAP4 has been shown to interact with: