Harman Patil

AKAP4

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Species  Human
Entrez  8852
Human  Mouse
Ensembl  ENSG00000147081
AKAP4
Aliases  AKAP4, AKAP 82, AKAP-4, AKAP82, CT99, FSC1, HI, PRKA4, hAKAP82, p82, A-kinase anchoring protein 4
External IDs  MGI: 102794 HomoloGene: 2887 GeneCards: AKAP4

A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene.

Contents

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Clinical significance

AKAP4 is a potential biomarker for early diagnosis and immunotherapy of colon cancer. AKAP4 may be implicated as a biomarker and immunotherapeutic target for cervical cancer. AKAP4 is also a circulating biomarker for non-small cell lung cancer.

Interactions

AKAP4 has been shown to interact with:

  • AKAP3, and
  • PRKAR1A.
  • References

    AKAP4 Wikipedia


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