Species Human Entrez 10566 | Human Mouse Ensembl ENSG00000111254 | |
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Aliases AKAP3, AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1, A-kinase anchoring protein 3 External IDs MGI: 1341149 HomoloGene: 4688 GeneCards: AKAP3 | ||
A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.
Contents
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
Interactions
AKAP3 has been shown to interact with: