Harman Patil


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Species  Human
Entrez  10566
Human  Mouse
Ensembl  ENSG00000111254
Aliases  AKAP3, AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1, A-kinase anchoring protein 3
External IDs  MGI: 1341149 HomoloGene: 4688 GeneCards: AKAP3

A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.



The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


AKAP3 has been shown to interact with:

  • AKAP4
  • GNA13, and
  • PRKAR2A.
  • References

    AKAP3 Wikipedia

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