Supriya Ghosh

ADAMTS1

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Species  Human
Entrez  9510
Human  Mouse
Ensembl  ENSG00000154734
ADAMTS1
Aliases  ADAMTS1, C3-C5, METH1, ADAM metallopeptidase with thrombospondin type 1 motif 1
External IDs  MGI: 109249 HomoloGene: 21381 GeneCards: ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

Contents

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.

Interactions

ADAMTS1 has been shown to interact with Vascular endothelial growth factor A.

References

ADAMTS1 Wikipedia


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