Trisha Shetty

ADAMTS10

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Species  Human
Entrez  81794
Human  Mouse
Ensembl  ENSG00000142303
ADAMTS10
Aliases  ADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDs  MGI: 2449112 HomoloGene: 81940 GeneCards: ADAMTS10

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

References

ADAMTS10 Wikipedia


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