Kalpana Kalpana

ADAMTS12

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Species  Human
Entrez  81792
Human  Mouse
Ensembl  n/a
ADAMTS12
Aliases  ADAMTS12, PRO4389, ADAM metallopeptidase with thrombospondin type 1 motif 12
External IDs  MGI: 2146046 HomoloGene: 12808 GeneCards: ADAMTS12

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.

References

ADAMTS12 Wikipedia


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