Harman Patil

ACACB

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
Species  Human
Entrez  32
Human  Mouse
Ensembl  ENSG00000076555
ACACB
Aliases  ACACB, ACC2, ACCB, HACC275, acetyl-CoA carboxylase beta
External IDs  MGI: 2140940 HomoloGene: 74382 GeneCards: ACACB

Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene.

Contents

Function

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyltransferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.

Clinical implications

Human acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity drugs. However, when the gene for ACC2 was knocked out in mice, no change in body weight was observed relative to normal mice. This result suggests inhibition of ACC2 by drugs may be an ineffective method of treating obesity.

References

ACACB Wikipedia


Similar Topics
Paulina Bisztyga
Cristian García Ramos
Jean Luc Fournier
Topics