Harman Patil


Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
Species  Human
Entrez  22
Human  Mouse
Ensembl  ENSG00000131269
Aliases  ABCB7, AA517758, AU019072, Abc7, ASAT, Atm1p, EST140535, ATP binding cassette subfamily B member 7
External IDs  MGI: 109533 HomoloGene: 3175 GeneCards: ABCB7

ATP-binding cassette sub-family B member 7, mitochondrial is a protein that in humans is encoded by the ABCB7 gene.



The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis.

Clinical significance

Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.


ABCB7 has been shown to interact with Ferrochelatase.


ABCB7 Wikipedia

Similar Topics
A Glimpse of Hell (film)
Francesca Martinez
Roxy DeVille