EC number 1.1.1.51 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9015-81-0 BRENDA BRENDA entry KEGG KEGG entry | |
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17β-Hydroxysteroid dehydrogenases (EC 1.1.1.51, beta-hydroxy steroid dehydrogenase, 17-ketoreductase, 17beta-hydroxy steroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase, 17β-HSD, 17-ketosteroid oxidoreductases, HSD17B, 17-ketosteroid reductases, 17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.
Contents
Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
Genes
Genes coding for 17β-HSD include:
Clinical significance
Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.
Some inhibitors of 17(-hydroxysteroid dehydrogenase type 1 were identified, for example esters of cinnamic acid and various flavones (e.g. Fisetin).