|Covid-19|January 12 – Gustav I of Sweden is crowned king of Sweden, having already reigned since his election in June 1523.
Peasant uprising in Dalarna, Sweden: rebel campaign fails and the rebel leader, later known as Daljunkern, flees to Rostock.
Diego García de Moguer explores the Sierra de la Plata along the Río de la Plata and begins to travel up the Paraná River.
Paracelsus visits Colmar in Alsace.
June 19 – Battle of Landriano: A French army in Italy under Marshal Francis de Bourbon, Count of St. Pol is decisively defeated.
September 12 – Andrea Doria defeats his former allies, the French, and establishes the independence of Genoa.
October 3 – Álvaro de Saavedra Cerón arrives in the Maluku Islands.
October 13 – Cardinal Thomas Wolsey founds a college in his birthplace of Ipswich in England, which becomes the modern-day Ipswich School (incorporating institutions in the town dating back to 1299).
October 20 – The Treaty of Gorinchem is signed between Charles V, Holy Roman Emperor, and Charles, Duke of Guelders.
November 6 – Spanish conquistador Álvar Núñez Cabeza de Vaca and his companions become the first known Europeans to set foot on the shores of what is present-day Texas.
Montenegro gains autonomy under Turkish power.
The Maya peoples drive Spanish Conquistadores out of Yucatán.
Spain takes direct control of Acapulco.
Bubonic plague breaks out in England.
The fourth major outbreak of the sweating sickness occurs in England. This time the disease also spreads to northern Europe.
St George's Chapel in Windsor Castle is completed.
Chateau Fontainebleau in France is begun.
Michelangelo Buonarroti begins work on the fortifications of Florence.
Baldassare Castiglione publishes The Book of the Courtier.
In Henan province of China, during the mid Ming Dynasty, a vast drought deprives the region of harvests for the next two years, killing off half the people in some communities due to starvation and cannibalism.
Paracelsus leaves Basle.
January 7 – Jeanne d'Albret, Queen of Navarre (d. 1572)
Domingo Báñez, Spanish theologian (d. 1604)
Albert V, Duke of Bavaria (d. 1579)
March 25 – Jakob Andreae, German theologian (d. 1590)
June 7 – Cyriacus Spangenberg, German theologian and historian (d. 1604)
June 21 – Maria of Austria, Holy Roman Empress (d. 1603)
June 29 – Julius, Duke of Brunswick-Lüneburg (d. 1589)
July 7 – Archduchess Anna of Austria, Duchess of Bavaria (d. 1590)
July 8 – Emmanuel Philibert, Duke of Savoy (d. 1580)
July 26 – Diego Andrada de Payva, Portuguese theologian (d. 1575)
August 10 – Eric II, Duke of Brunswick-Lüneburg (d. 1584)
September 25 – Otto II, Duke of Brunswick-Harburg (d. 1603)
October 4 – Francisco Guerrero, Spanish composer (d. 1599)
October 10 – Adam Lonicer, German botanist (d. 1586)
November 2 – Petrus Lotichius Secundus, German Neo-Latin Poet (d. 1560)
November 6 – Gabriel Goodman (d. 1601)
November 12 – Qi Jiguang, Chinese military general (d. 1588)
November 14 – Francisco Pérez de Valenzuela, Spanish noble (d. 1599)
November 29 – Anthony Browne, 1st Viscount Montagu, English politician (d. 1592)
Igram van Achelen, Dutch statesman (d. 1604)
Federico Barocci, Italian painter (d. 1612)
Adam of Bodenstein, Swiss alchemist and physician (d. 1577)
Jean-Jacques Boissard, French antiquary and Latin poet (d. 1602)
Andrei Kurbskii, Russian writer (d. 1583)
George Talbot, 6th Earl of Shrewsbury, English statesman (d. 1590)
Phung Khac Khoan, Vietnamese military strategist, politician, diplomat and poet (d. 1613)
Sabina, Duchess of Bavaria (d. 1578)
Thomas Whythorne, English musician and author (d. 1595)
Ambrose Dudley, 3rd Earl of Warwick, English general (d. 1590)
Paul de Foix French diplomat
Jean de Ligne, Duke of Aremberg, stadtholder of the Dutch provinces of Friesland (d. 1568)
Akechi Mitsuhide, Japanese samurai and warlord (d. 1582)
Costanzo Porta, Italian composer (d. 1601)
February 29 – Patrick Hamilton, Scottish religious reformer (martyred) (b. 1504)
March 10 – Balthasar Hübmaier, influential German/Moravian Anabaptist leader (b. 1480)
April 1 – Francisco de Peñalosa, Spanish composer (b. c. 1470)
April 6 – Albrecht Dürer, German artist, writer, and mathematician (b. 1471)
July – Palma il Vecchio, Italian painter (b. 1480)
August 15 – Odet de Foix, Vicomte de Lautrec, French military leader (b. 1485)
August 20 – Georg von Frundsberg, German knight and landowner (b. 1473)
August 31 – Matthias Grünewald, German artist (b. 1470)
September – Pánfilo de Narváez, Spanish conqueror and soldier in the Americas (b. 1480)
October 5 – Richard Foxe, English churchman (b. c. 1448)
Giovanni da Verrazzano, Italian explorer (b. 1485)
Peter Vischer the Younger, German sculptor (b. 1487)
Muhammad Tour, ruler of Gao
Daljunkern, Swedish rebel leader who may have been pretender Nils Sture (b. 1512)
Barbro Stigsdotter, Swedish noblewoman and heroine (b. 1472)
Year 1528 (MDXXVIII) was a leap year starting on Wednesday (link will display the full calendar) of the Julian calendar.