|Covid-19|January 17 – Florentine explorer Giovanni da Verrazzano, on board La Dauphine in the service of Francis I of France, sets out from Madeira for the New World to seek out a westabout sea route to the Pacific Ocean.
March – Spanish conquistador Pedro de Alvarado destroys the K'iche' kingdom of Q'umarkaj, taking the capital, Quiché.
March 1 (approximate date) – da Verrazzano's expedition makes landfall at Cape Fear.
April 17 – Verrazzano's expedition makes the first European entry into New York Bay and sights the island of Manhattan.
April 30 – Spanish forces under Charles de Lannoy defeat the French army in Italy under William de Bonnivet in the Battle of the Sesia. The French, now commanded by François de St. Pol, withdraw from the Italian Peninsula.
June 8 – Spanish conquistador Pedro de Alvarado leads the Battle of Acajutla, defeating a battalion of Pipiles, in the neighborhoods of present day Acajutla, El Salvador
Summer – Paracelsus visits Salzburg. He also visits Villach during the year.
July 8 – Verrazzano's expedition returns to Dieppe.
August–September – Marseille is besieged by Imperial forces under the Duke of Bourbon.
Late August – Protestant theologians Martin Luther and Andreas Karlstadt dispute at Jena.
October 28 – A French army invading Italy under King Francis besieges Pavia.
December 8 – Francisco Hernandez de Cordoba founds the city of Granada, Nicaragua, the oldest Hispanic city in the mainland of the Western Hemisphere.
The first Dalecarlian rebellions in Sweden.
February 10 – Albrecht Giese, German politician and diplomat (d. 1580)
February 17 – Charles, Cardinal of Lorraine, French cardinal (d. 1574)
February 24 – Wenceslaus III Adam, Duke of Cieszyn (d. 1579)
March 17 – Diego de Landa, Bishop of the Yucatán (d. 1579)
May 28 – Selim II, Ottoman Sultan (d. 1574)
June 12 – Achilles Statius, Portuguese humanist (d. 1581)
June 24 – Johann Stössel, German theologian (d. 1576)
August 14 – Elizabeth of Denmark, Duchess of Mecklenburg, Danish princess (d. 1586)
August 23 – François Hotman, French Protestant lawyer and writer (d. 1590)
September 7 – Thomas Erastus, Swiss theologian (d. 1583)
September 11 – Pierre de Ronsard, French poet (d. 1585)
October 4 – Francisco Vallés, Spanish physician (d. 1592)
October 5 – Rani Durgavati, Queen of Gond (d. 1564)
October 16 – Nicolas, Duke of Mercœur, Roman Catholic bishop (d. 1577)
Jan Borukowski, royal secretary of Poland (d. 1584)
Armand de Gontaut, baron de Biron, French soldier (d. 1592)
Jean Pithou, French lawyer and author (d. 1602); and his twin brother, Nicolas Pithou, French lawyer and author (d. 1598)
Thomas Tusser, English poet and farmer (d. 1580)
Luís de Camões, Portuguese poet (d. 1580)
Catherine Howard, Fifth Queen of Henry VIII of England, (born in between 1518 and 1524; d. 1542)
January 5 – Marko Marulić, Croatian poet (b. 1450)
February 20 – Tecun Uman, K'iche' Mayan ruler (b. c. 1500)
April 30 – Pierre Terrail, seigneur de Bayard, French soldier (b. 1473)
May 21 – Thomas Howard, 2nd Duke of Norfolk, English soldier and statesman (b. 1443)
May 23 – Ismail I, Safavid dynasty Shah of Persia (b. 1487)
June 12 – Diego Velázquez de Cuéllar, Spanish conquistador (b. 1465)
July 20 – Claude of France, queen consort of Louis XII of France (b. 1499)
August 24 – William Scott, English Lord Warden of the Cinque Ports (b. 1459)
October 5 – Joachim Patinir, Flemish landscape painter (b. c. 1480)
December 20 – Thomas Linacre, English humanist and physician (b. 1460)
December 24 – Vasco da Gama, Portuguese explorer (b. c. 1469)
Hans Holbein the Elder, German painter (b. 1460)
Andrea Solari, Italian painter (b. 1460)
Tang Yin, Chinese painter (b. 1470)
Year 1524 (MDXXIV) was a leap year starting on Friday (link will display the full calendar) of the Julian calendar.