|Covid-19|June 19 – Zhengde Emperor ascends the throne of the Ming Dynasty.
June 27 – The future King Henry VIII of England repudiates his engagement to Catherine of Aragon, at his father's command.
July 2 – Martin Luther, then 22, vows to become a monk in a moment of terror, due to a near lightning strike during a thunderstorm, near the village of Stotternheim.
July – The Kalmar Bloodbath take place in Kalmar in Sweden.
July 17 – Luther enters the monastic life at an Augustinian cloister in Erfurt.
July 24 – Travelling to India, a group of Portuguese explorers sack the city-state of Kilwa in East Africa, killing the king for failing to pay tribute.
November 6 – Vasili III succeeds Ivan III as Grand Prince of Muscovy.
December 18 – John IX van Horne, prince-bishop of Lièges, Belgium, is executed.
A Portuguese fleet attacks Kilwa and then Mombasa. The Portuguese then attempt to monopolize the trade in the east African ports, but are unable to maintain control (by the late 16th century, Swahili groups regain control of several ports from the Portuguese).
Portuguese merchants establish factories on the east coast of Africa.
Portuguese under Dom Lourenço d'Almeida reach Colombo, Sri Lanka, and send envoys to King of Kotte; they also reach the Comoros.
Bermuda is discovered by Spanish explorer Juan de Bermúdez.
King Alexander of Poland signs the Nihil novi Act, making Poland a Nobles' Democracy.
Poland prohibits peasants from leaving their lands, establishing serfdom.
Christ's College, Cambridge, is re-founded, receiving its charter from Lady Margaret Beaufort.
Judah Abravanel becomes personal physician to the viceroy of Naples.
Battle of Achnashellach said to have taken place in Scotland.
The M8.2–8.8 Lo Mustang earthquake struck Nepal, causing severe damage in Kathmandu, western Nepal, and some parts of Indo-Gangetic plain.
1505 or 1506 - Portuguese explorer Gonçalo Álvares is the first to sight what will later be known as Gough Island in the South Atlantic.
January 12 – Louis, Count of Stolberg, German nobleman (d. 1574)
January 13 – Joachim II Hector, Elector of Brandenburg, Imperial Elector (d. 1571)
February 4 – Mikołaj Rej, Polish poet and prose writer, politician and musician of the Renaissance (d. 1569)
February 5 – Aegidius Tschudi, Swiss historian (d. 1572)
March 16 – Francisco Balbi di Correggio (d. 1589)
March 25 – Elizabeth Grey, Viscountess Lisle, Heiress (d. 1519)
May 20 – Levinus Lemnius, Dutch writer (d. 1568)
September 15 – Mary of Hungary, Dutch ruler (d. 1558)
September 23 – Anne de Laval, Viscountess of Thouars, French noblewoman and nominal pretender to the Kingdom of Naples (d. 1554)
November 3 – Achilles Gasser, German physician and astrologer (d. 1577)
November 23 – Ercole Gonzaga, Catholic cardinal (d. 1563)
December 18 – Philipp von Hutten, German explorer (d. 1546)
December 21 – Thomas Wriothesley, 1st Earl of Southampton, English politician (d. 1550)
December 25 – Christine of Saxony, German noble (d. 1549)
William Cavendish, English courtier (d. 1557)
Philip Hoby, English politician (d. 1558)
Guillaume Morel, French classical scholar (d. 1564)
Shahghali, Khan of Qasim
probable – Christopher Tye, English composer and organist (d. 1572)
February 4 – Jeanne de Valois, daughter of Louis XI of France (b. 1464)
February 20 – Arvid Trolle, Swedish politician (b. c. 1440)
April 23 – Muhammad Jaunpuri, Indian-born religious leader (b. 1443)
June 8 – Hongzhi Emperor of China (b. 1470)
June 15 – Ercole d'Este I, Duke of Ferrara (b. 1431)
July – Jacob Obrecht, Flemish composer (plague) (b. 1457)
October 27 – Ivan III of Russia (b. 1440)
Adam of Fulda, German music writer (b. c. 1445)
Heinrich Kramer, German churchman and inquisitor (b. 1430)
Year 1505 (MDV) was a common year starting on Wednesday (link will display the full calendar) of the Julian calendar.