Year 1480 (MCDLXXX) was a leap year starting on Saturday (link will display the full calendar) of the Julian calendar.
March 6 – Treaty of Toledo: Ferdinand and Isabella of Spain recognize the African conquests of Afonso of Africa, and he cedes the Canary Islands to Spain. (?? see Treaty of Alcáçovas )
July 28
Mehmed II fails in his attempt to capture Rhodes from the Knights of Rhodes.
An Ottoman army lands near Otranto, Italy. Pope Sixtus IV calls for a crusade to drive it away.
August 12 - Ottoman invasion of Otranto - Ottoman troops behead 800 Christians for refusing to convert to Islam. The Martyrs of Otranto are canonized in 2013.
September 27 – Consorts and co-rulers Ferdinand II of Aragon and Isabella I of Castile initiate the Spanish Inquisition (looking for heretics and unconverted Jews).
October – Great stand on the Ugra river: Muscovy becomes independent from the Golden Horde. The Theotokos of Vladimir icon is credited with saving Moscow.
The Lighthouse of Alexandria's final remains disappear when Qaitbay, Sultan of Egypt, builds the Citadel of Qaitbay on its site.
Magdalen College School, Oxford, established by William Waynflete.
January 10 – Margaret of Austria, Regent of the Netherlands (d. 1530)
February 3 – Fernão de Magalhães, Portuguese navigator (d. 1521)
February 12 – Frederick II of Legnica, Duke of Legnica from 1488 (until 1495 and 1505 with his brothers) (d. 1547)
February 13 – Girolamo Aleandro, Italian cardinal (d. 1542)
April 10 – Philibert II, Duke of Savoy (d. 1504)
April 14 – Lucrezia Borgia, Duchess of Ferrara (d. 1519)
June 1 – Tiedemann Giese, Catholic bishop from Danzig (Gdańsk) in Poland (d. 1550)
July 5 – Philip of the Palatinate, Bishop of Freising and Naumburg (d. 1541)
October 1 – Saint Cajetan, Italian Catholic priest and religious reformer (d. 1547)
November 10 – Bridget of York, English nun (d. 1517)
October – Saint Cajetan, founder of the Theatines (d. 1547)
date unknown
Vannoccio Biringuccio, Italian metallurgist (d. 1539)
Claude Garamond, French publisher (d. 1561)
Giovanni Guidiccioni, Italian poet (d. 1541)
Ferdinand Magellan, Portuguese explorer (d. 1521)
Jerzy Radziwiłł, Polish nobleman (d. 1541)
Palma il Vecchio, Italian painter (d. 1528)
probable
Arasibo, Taino Cacique
Hans Baldung, German painter (d. 1545)
Matteo Bandello, Italian novelist (d. 1562)
Johann Georg Faust, German alchemist (d. 1540)
Jumacao, Taino Cacique
Conn O'Neill, 1st Earl of Tyrone (d. 1559)
Marcantonio Raimondi, Italian engraver (d. c. 1534)
April 14 – Thomas de Spens, Scottish statesman and prelate (b. c. 1415)
May 19 – Jan Długosz, Polish historian (b. 1415)
June 6 – Vecchietta, Italian painter, sculptor and architect (b. c. 1410)
July 6 – Antonio Squarcialupi, Italian composer (b. 1416)
July 10 – King René I of Naples (b. 1409)
September 1 – Ulrich V, Count of Württemberg (b. 1413)
December 14 – Niccolò Perotti, humanist scholar (b. 1429)
date unknown
Nicolas Jenson, French engraver (b. 1420)
Tristão Vaz Teixeira, explorer (b. c. 1395)
Antonio Vivarini, Italian painter (b. c. 1440)
1480 Wikipedia (Text) CC BY-SA