|Covid-19|April – Tarabya and Studius are taken by the Ottoman Empire in preparation for the assault on Constantinople, as are the Prince Islands, by the Ottoman fleet under Admiral Baltaoglu.
April 6–May 29 – Siege and Fall of Constantinople: The Ottoman Sultan Mehmed the Conqueror ends the Byzantine (or Eastern Roman) Empire after more than a thousand years by capturing the capital, Constantinople (modern-day Istanbul). Mortars are perhaps used in battle for the first time in this action. The consequent closure of the traditional overland route from Western Europe to the Far East and need to identify new maritime routes leads to the Age of Discovery and ends the Middle Ages.
May 22 – Partial lunar eclipse.
July – Revolt of Ghent: Philip the Good, Duke of Burgundy, crushes the Ghent rebellion.
July 17 – Battle of Castillon: The French under Jean Bureau defeat the English under the Earl of Shrewsbury, who was killed.
October 10 – Sejo of Joseon killed his enemy Kim Jongseo, and gained control of the government. In Korean, this rebellion is called Gyeyujeongnan.
October 19 – The Hundred Years' War comes to a close with the French recapture of Bordeaux, leaving the English retaining only Calais on French soil.
January 1 – Bernardin Frankopan, Croatian nobleman, diplomat and soldier (d. 1529)
February 6 – Girolamo Benivieni, Florentine poet (d. 1542)
March 2 – Johannes Engel (d. 1512)
March 3 – Philip II, Count of Waldeck-Eisenberg (1486–1524) (d. 1524)
March 25 – Giuliano de' Medici (d. 1478)
April 18 – Margaret of Brandenburg, abbess of the Poor Clares monastery at Hof (d. 1509)
May 13 – Mary Stewart, Countess of Arran, Scottish princess (d. 1488)
June 10 – Francesco Soderini, Catholic cardinal (d. 1524)
September 1 – Gonzalo Fernández de Córdoba, Spanish general and statesman (d. 1515)
October 13 – Edward of Westminster, Prince of Wales (d. 1471)
November 13 – Christoph I, Margrave of Baden-Baden (1475–1515) (d. 1527)
November 17 – Alfonso, Prince of Asturias (d. 1468)
date unknown – Jacob Obrecht, Flemish composer (d. 1505)
probable – Afonso de Albuquerque, Portuguese admiral (d. 1515)
February 28 – Isabella, Duchess of Lorraine (b. 1400)
Constantine XI Palaiologos, last Byzantine Emperor ("Last Roman Emperor")
Ecumenical Patriarch Athanasius II of Constantinople (all killed in, or shortly after, the siege of Constantinople)
Demetrios Palaiologos Metochites, last governor of Constantinople
June 1 – Giovanni Giustiniani, Italian captain
June 2 – Álvaro de Luna, Duke of Trujillo, Constable of Castile
June 3 – Loukas Notaras, last megas doux of the Byzantine Empire
June 4 – Andronikos Palaiologos Kantakouzenos, last Grand Domestic of the Byzantine Empire
Dmitry Shemyaka, Grand Prince of Moscow 1445, 1446–1447, poisoned in Veliky Novgorod by Vasily Tyomny's agents
John Talbot, 1st Earl of Shrewsbury, English military leader
July 20 – Enguerrand de Monstrelet, French chronicler
December 24 – John Dunstaple, English composer (b. 1390)
Demetrius III, former co-king of Georgia (b. c. 1413)
Year 1453 (MCDLIII) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. It is sometimes cited as the notional end of the Middle Ages by historians who define the medieval period as the time between the Fall of the Western Roman Empire and the fall of the Byzantine (Eastern Roman) Empire.