|CAS Number 573-22-8|
|PubChem CID 225683|
|Synonyms THP-1; 1,2,3,4-Tetrahydrophenanthren-1-one|
1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1), or 1,2,3,4-tetrahydrophenanthren-1-one, is a synthetic, steroid-like estrogen, and was reported to be the first synthetic estrogen, or the first synthetic compound identified with estrogenic activity. It was first synthesized in 1933 by Cook et al and was tested due to its similarity to the presumed chemical structure of estrone. Upon reassessment many decades later, the compound was found to bind only weakly to the estrogen receptors and, unexpectedly, was without functional activity as an estrogen or antiestrogen in vitro or in vivo. It did, however, show some androgenic and antiandrogenic activity in vitro.