Girish Mahajan (Editor)

1 Keto 1,2,3,4 tetrahydrophenanthrene

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CAS Number
  
573-22-8

ChemSpider
  
196209

Formula
  
C14H12O2

PubChem CID
  
225683

ChEMBL
  
CHEMBL88130

1-Keto-1,2,3,4-tetrahydrophenanthrene

Synonyms
  
THP-1; 1,2,3,4-Tetrahydrophenanthren-1-one

1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1), or 1,2,3,4-tetrahydrophenanthren-1-one, is a synthetic, steroid-like estrogen, and was reported to be the first synthetic estrogen, or the first synthetic compound identified with estrogenic activity. It was first synthesized in 1933 by Cook et al and was tested due to its similarity to the presumed chemical structure of estrone. Upon reassessment many decades later, the compound was found to bind only weakly to the estrogen receptors and, unexpectedly, was without functional activity as an estrogen or antiestrogen in vitro or in vivo. It did, however, show some androgenic and antiandrogenic activity in vitro.

References

1-Keto-1,2,3,4-tetrahydrophenanthrene Wikipedia


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