Samiksha Jaiswal (Editor)

1,2,4 Trichlorobenzene

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Appearance  Colorless liquid
Boiling point  214.4 °C
Density  1.46 g/cm³
Formula  C6H3Cl3
Molar mass  181.45 g/mol
Melting point  16.9 °C
1,2,4-Trichlorobenzene File124Trichlorobenzene 2svg Wikimedia Commons

1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. It is a derivative of benzene with three chloride substituents. It is a colorless liquid used as a solvent for a variety of compounds and materials.


1,2,4-Trichlorobenzene 124triclorobenzene Wikipedia

Production and uses

1,2,4-Trichlorobenzene wwwsigmaaldrichcomcontentdamsigmaaldrichstr

Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. It is virtually the exclusive product from the chlorination of 1,4-dichlorobenzene. It is also the main product from the dehydrochlorination of hexachlorocyclohexane.

1,2,4-Trichlorobenzene 124trichlorobenzene C6H3Cl3 ChemSynthesis

It is useful as a high-temperature solvent, e.g. for GPC of polyolefines such as PE or PP which are otherwise insoluble.

Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides.


1,2,4-Trichlorobenzene 124trichlorobenzene C6H3Cl3 PubChem

The LD50 (oral, rats) is 756 mg/kg. Animal studies have shown that 1,2,4-Trichlorobenzene affects the liver and kidney, and is possibly a teratogen. There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday.

1,2,4-Trichlorobenzene 124Trichlorobenzene C6H3Cl3 ChemSpider


1,2,4-Trichlorobenzene Wikipedia