Species Human Entrez 140883 | Human Mouse Ensembl n/a | |
Aliases ZNF280B, 5'OY11.1, D87009.C22.3, SUHW2, ZNF279, ZNF632, zinc finger protein 280B External IDs MGI: 1927865 HomoloGene: 62794 GeneCards: ZNF280B | ||
Gene music using protein sequence of znf280b zinc finger protein 280b
Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.
Contents
Function
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.
References
Zinc finger protein 280b Wikipedia(Text) CC BY-SA