Species Human Entrez 7704 | Human Mouse Ensembl ENSG00000109906 | |
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Aliases ZBTB16, PLZF, ZNF145, zinc finger and BTB domain containing 16 External IDs MGI: 103222 HomoloGene: 21214 GeneCards: ZBTB16 | ||
Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Contents
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with: