Symbol Ydc2-catalyt Pfam clan CL0219 SCOP 1kcf | Pfam PF09159 InterPro IPR015242 SUPERFAMILY 1kcf | |
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In molecular biology, the protein domain, Ydc2 (also known as SpCce1), is a Holliday junction resolvase from the fission yeast Schizosaccharomyces pombe that is involved in the maintenance of mitochondrial DNA.
Contents
Function
In molecular biology, the Ydc2 domains are enzymes, or in other words biological catalysts, capable of resolving Holliday junctions into separate DNA duplexes by cleaving DNA after 5'-CT-3, and 5'-TT-3, sequences.
Properties
The junction resolving enzymes are very diverse, but have the following properties in common:
Essentially, they are highly specific.
Limiting factors
Furthermore, the cleavage efficiency is affected by:
Structure
This protein domain forms a ribonuclease H fold consisting of two beta sheets and one alpha helix, arranged as a beta-alpha-beta motif. Each beta sheet has five strands, arranged in a 32145 order, with the second strand being antiparallel to the rest.