Species Human Entrez 7465 | Human Mouse Ensembl ENSG00000166483 | |
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Aliases WEE1, WEE1A, WEE1hu, WEE1 G2 checkpoint kinase External IDs MGI: 103075 HomoloGene: 31152 GeneCards: WEE1 | ||
WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.
Contents
Function
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
Interactions
Wee1-like protein kinase has been shown to interact with YWHAB and PIN1.
References
Wee1-like protein kinase Wikipedia(Text) CC BY-SA