Entrez 11059 | Ensembl ENSG00000123124 | |
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Aliases WWP1, AIP5, Tiul1, hSDRP1, WW domain containing E3 ubiquitin protein ligase 1 External IDs MGI: 1861728 HomoloGene: 21385 GeneCards: WWP1 | ||
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.
Contents
Function
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.
Interactions
WWP1 has been shown to interact with: