Formula C29H36O15 Pubchem 5281800 | Molar mass 624.59 g/mol | |
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How to pronounce verbascoside
Verbascoside is a caffeoyl phenylethanoid glycoside (CPG). It is an ester formed with the phenylethanoid hydroxytyrosol, the phenylpropanoid caffeic acid and the sugar alpha-L-rhamnopyranosyl-(1->3)-beta-D-glucopyranose.
Contents
- How to pronounce verbascoside
- Natural occurrences
- Derivatives
- In in vitro cultures
- Biological activity
- References

Natural occurrences

Verbascoside can be found in species in all the families of the Lamiales order (syn. Scrophulariales). Only two examples are known from outside the order, in the clade Asterids.

In the family Lamiaceae, it can be found in the medicinal plants in the genus Phlomis, in the Scrophulariaceae, in Verbascum phlomoides, Verbascum mallophorum, or, in the Buddlejaceae family, in Buddleja globosa or Buddleja cordata, in the Bignoniaceae family, in Pithecoctenium sp and Tynanthus panurensis, in the Orobanchaceae family, in Cistanche sp and Orobanche rapum-genistae, in the Plantaginaceae, in Plantago lanceolata, in Verbenaceae, in Verbena officinalis (common vervain), Aloysia citrodora (lemon verbena) and Lantana camara, in the Oleaceae, in Olea europaea (olive), in the Lentibulariaceae, in the carnivorous plant Pinguicula lusitanica, and, in the Byblidaceae, in Byblis liniflora.
Derivatives
Verbascoside derivatives can be found in the Verbascum undulatum and notably apiosides in Verbascum sp.
In in vitro cultures

It can also be produced in plant cell cultures of Leucosceptrum sp (Lamiaceae) and Syringa sp (Oleaceae). It can also be produced in hairy roots cultures of Paulownia tomentosa (empress tree, Paulowniaceae).
Biological activity
Verbascoside has an antimicrobial activity, notably against Staphylococcus aureus. It can also have anti-inflammatory properties.

Although some in vitro genotoxicity of verbascoside has been reported on human lymphocytes with an involvement of PARP-1 and p53 proteins, subsequent in vivo tests reported no genotoxicity for high dosage oral administration. It is a protein kinase C inhibitor.
