Trisha Shetty (Editor)

Vanadocene dichloride

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Abbreviations
  
Cp2VCl2

Molar mass
  
252.03 g/mol

Appearance
  
Green solid

Formula
  
C10H10Cl2V

Density
  
1.7 g/cm³

Vanadocene dichloride wwwsigmaaldrichcomcontentdamsigmaaldrichstr

Related compounds
  
Titanocene dichloride Zirconocene dichloride Hafnocene dichloride Niobocene dichloride Tanatalocene dichloride Molybdenocene dichloride Tungstenocene dichloride

Vanadocene dichloride is an organometallic complex with formula (η5-C5H5)2VCl2 (commonly abbreviated as Cp2VCl2). It is a structural analogue of titanocene dichloride but with vanadium(IV) instead of titanium(IV). This compound has one unpaired electron, hence Cp2VCl2 is paramagnetic. Vanadocene dichloride is a suitable precursor for variety of bis(cyclopentadienyl)vanadium(IV) compounds.

Contents

Reduction of vanadocene dichloride gives vanadocene, (C5H5)2V.

Preparation

Cp2VCl2 was first prepared by Wilkinson and Birmingham via the reaction of NaC5H5 and VCl4 in THF, followed by work up by extraction with chloroform and hydrogen chloride and recrystallization from toluene.

Structure

Like titanocene dichloride, this organovanadium compound is currently being investigated as a potential anticancer drug (currently in clinical trials). The mechanism by which it acts is not understood, but some conjecture that it might be due to its interactions with the protein transferrin.

References

Vanadocene dichloride Wikipedia
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