Van Rooyen or Van Rooijen is an Afrikaans and Dutch toponymic surname. Notable people with the surname include:
Ack van Rooyen (born 1930), Dutch jazz trumpetistBasil van Rooyen (born 1939), South African racing driverDavid van Rooyen, South African politicianGert van Rooyen (c. 1954 – 1990), South African serial killerJacques van Rooyen (born 1986), South African rugby playerJerry van Rooyen, born "Gerard van Rooijen" (1928–2009), Dutch trumpeter, conductor, and composerManon van Rooijen (born 1982), Dutch swimmerMaurits van Rooijen (born 1956), Dutch social and economic historianReynier van Rooyen (born 1990), South African rugby union playerShaun van Rooyen (born 1987), New Zealand soccer player