Van Rooyen or Van Rooijen is an Afrikaans and Dutch toponymic surname. Notable people with the surname include:
Ack van Rooyen (born 1930), Dutch jazz trumpetist
Basil van Rooyen (born 1939), South African racing driver
David van Rooyen, South African politician
Gert van Rooyen (c. 1954 – 1990), South African serial killer
Jacques van Rooyen (born 1986), South African rugby player
Jerry van Rooyen, born "Gerard van Rooijen" (1928–2009), Dutch trumpeter, conductor, and composer
Manon van Rooijen (born 1982), Dutch swimmer
Maurits van Rooijen (born 1956), Dutch social and economic historian
Reynier van Rooyen (born 1990), South African rugby union player
Shaun van Rooyen (born 1987), New Zealand soccer player
