Entrez 8615 | Ensembl ENSG00000138768 | |
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Aliases USO1, P115, TAP, VDP, USO1 vesicle transport factor External IDs MGI: 1929095 HomoloGene: 2754 GeneCards: USO1 | ||
General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.
Contents
Function
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GOLGA2, and giantin in a sequential manner.
Interactions
USO1 has been shown to interact with: