USF1

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.

A study of mice suggested reduced USF1 levels increases metabolism in brown fat.

Interactions

USF1 (human gene) has been shown to interact with USF2, FOSL1 and GTF2I.