Species Human Entrez 8061 | Human Mouse Ensembl ENSG00000175592 | |
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Aliases FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 trancription factor subunit, FOS like 1, AP-1 transcription factor subunit External IDs MGI: 107179 HomoloGene: 3967 GeneCards: FOSL1 | ||
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.
Contents
Function
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Interactions
FOSL1 has been shown to interact with USF1 (human gene) and C-jun.
References
FOSL1 Wikipedia(Text) CC BY-SA