Entrez 7353 | Ensembl ENSG00000070010 | |
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Aliases UFD1, UFD1L, ubiquitin fusion degradation 1 like (yeast) External IDs MGI: 109353 HomoloGene: 39090 GeneCards: UFD1 | ||
Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.
Contents
Function
The protein encoded by this gene forms a complex with two other proteins, NPL4 and VCP, that is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms.
Interactions
UFD1L has been shown to interact with NPLOC4.
References
UFD1L Wikipedia(Text) CC BY-SA