Entrez 55666 | Ensembl ENSG00000182446 | |
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Aliases NPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor External IDs MGI: 2679787 HomoloGene: 5403 GeneCards: NPLOC4 | ||
Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.
Contents
Model organisms
Model organisms have been used in the study of NPLOC4 function. A conditional knockout mouse line, called Nploc4tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and two phenotypes were reported. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no significant abnormalities were observed in these animals.
Interactions
NPLOC4 has been shown to interact with UFD1L.