Species Human Entrez 7343 | Human Mouse Ensembl ENSG00000108312 | |
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Aliases UBTF, NOR-90, UBF, UBF-1, UBF1, UBF2, upstream binding transcription factor, RNA polymerase I External IDs MGI: 98512 HomoloGene: 7970 GeneCards: UBTF | ||
Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.
Contents
Function
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]
Interactions
UBTF has been shown to interact with:
References
UBTF Wikipedia(Text) CC BY-SA