Neha Patil (Editor)

UBTF

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Species
  
Human

Entrez
  
7343

Human
  
Mouse

Ensembl
  
ENSG00000108312

UBTF httpsmediascbtcomproduct2939z293946jpg

Aliases
  
UBTF, NOR-90, UBF, UBF-1, UBF1, UBF2, upstream binding transcription factor, RNA polymerase I

External IDs
  
MGI: 98512 HomoloGene: 7970 GeneCards: UBTF

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.

Contents

Function

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM]

Interactions

UBTF has been shown to interact with:

  • CSNK2A1,
  • RB1,
  • TAF1C, and
  • TAF1.

    • References

    UBTF Wikipedia
    (Text) CC BY-SA


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