Entrez 9013 | Ensembl ENSG00000103168 | |
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Aliases TAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C External IDs MGI: 109576 HomoloGene: 21163 GeneCards: TAF1C | ||
TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.
Contents
Function
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.
Interactions
TAF1C has been shown to interact with UBTF.
References
TAF1C Wikipedia(Text) CC BY-SA