Species Human Entrez 51366 | Human Mouse Ensembl ENSG00000104517 | |
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Aliases UBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5 External IDs MGI: 1918040 HomoloGene: 9295 GeneCards: UBR5 | ||
E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.
Contents
Function
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
Interactions
UBR5 has been shown to interact with:
References
UBR5 Wikipedia(Text) CC BY-SA