Neha Patil (Editor)

UBR5

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Species
  
Human

Entrez
  
51366

Human
  
Mouse

Ensembl
  
ENSG00000104517

UBR5

Aliases
  
UBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5

External IDs
  
MGI: 1918040 HomoloGene: 9295 GeneCards: UBR5

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

Contents

Function

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Interactions

UBR5 has been shown to interact with:

  • CIB1,
  • Karyopherin alpha 1,
  • MAPK1, and
  • TOPBP1.

    • References

    UBR5 Wikipedia
    (Text) CC BY-SA


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