Entrez 11073 | Ensembl ENSG00000163781 | |
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Aliases TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1 External IDs MGI: 1920018 HomoloGene: 38262 GeneCards: TOPBP1 | ||
DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.
Contents
Function
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.
Interactions
TOPBP1 has been shown to interact with:
Clinical relevance
This gene may be involved in the development of ovarian and breast cancer.
Mutations in TOPBP1 cause Idiopathic pulmonary arterial hypertension .
References
TOPBP1 Wikipedia(Text) CC BY-SA