Harman Patil (Editor)

TOPBP1

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Species
  
Human

Entrez
  
11073

Human
  
Mouse

Ensembl
  
ENSG00000163781

TOPBP1

Aliases
  
TOPBP1, TOP2BP1, topoisomerase (DNA) II binding protein 1

External IDs
  
MGI: 1920018 HomoloGene: 38262 GeneCards: TOPBP1

DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.

Contents

Function

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Interactions

TOPBP1 has been shown to interact with:

Clinical relevance

This gene may be involved in the development of ovarian and breast cancer.

Mutations in TOPBP1 cause Idiopathic pulmonary arterial hypertension .

References

TOPBP1 Wikipedia