EC number 2.3.2.24 Human Mouse | Species Human Entrez 7323 | |
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Aliases UBE2D3, E2(17)KB3, UBC4/5, UBCH5C, ubiquitin conjugating enzyme E2 D3 External IDs MGI: 1913355 HomoloGene: 123914 GeneCards: UBE2D3 | ||
Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.
Contents
Function
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
Interactions
UBE2D3 has been shown to interact with NEDD4.